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Botanical Name :
Leptadenia reticulata
Sanskrit Name:
Jivanti, Jivani, Madhusrava
English Name :
Jivanti,
jiwanti
Family : Asclpiadaceae
Part used: leaf
Description of
Leptadenia reticulata:
It grows in the sub-Himalayan tracts of Punjab, U.P. and
throughout the Deccan Peninsula up to an altitude of 900 m, in
India.
L.reticulata is a much-branched twining shrub. The bark
is yellowish brown, corky, deeply cracked; the leaves are ovate-cordate,
coriaceous glabrous above, more or less finely pubescent
beneath; the flowers are in many-flowered cymes, greenish
yellow; the follicles are sub-woody and turgid. |
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Principal Constituents:
The plant contains a triterpenoid, leptadenol (C30H50O). It
also contained n -triacontane, cetyl alcohol, ß-sitosterol, ß-amyrin
acetate, lupanol 3-O -diglucoside and leptidin.
Pharmacology:
A number of studies have been carried out on the
galactagogue property of the plant in laboratory animals.
Studies on the lactogenic property of L.reticulata were
carried out on lactating rats using pup weight, body weight of
mother rats, and histopathological study of lactating mammary
gland, as well as the secretory rating, parenchyma percentage,
estimation of glycogen content (of the abdominal mammary glands)
and the protein content (of the pectoral mammary glands) as
parameters. While both stigmasterol and the ether fraction of
L.reticulata showed lactogenic effect, as assessed by all
these parameters, stigmasterol was found to be more potent2.A
herbal preparation with L.reticulata as one of the nine
constituents is said to exert beneficial effects on the
gametogenic and androgenic functions of the testes of animals.
It showed anabolic cum androgen like activity as evidenced by
the dose related growth of the ventral prostate and the systemic
increase in the weights as well as the secretions of the
accessory sex organs of castrated adult mice.
Clinical Studies:
The lactogenic/galactagogue effect of L.reticulata has
been clinically assessed by many investigators. These studies
have been mainly carried out on the commercial preparation of
Leptaden.
Toxicity:
On acute toxicity studies, L.reticulata (aqueous extract)
and leptaden administered orally for three alternate days, and
three consecutive days to rats, were safely tolerated up to a
dose of 3.125 g/kg. An increase in dose led to an increase in
mortality. Post mortem, subcutaneous peticheal hemorrhage was
noted, whilst the liver, kidney and heart showed no apparent
change.
Indications:
The plant is stimulant and restorative and shows anti-bacterial
activity against gram-positive and gram-negative bacteria.
Herbal Extract packing:
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