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Principal Constituents:
The plant contains a triterpenoid, leptadenol (C30H50O). It
also contained n -triacontane, cetyl alcohol, ß-sitosterol, ß-amyrin
acetate, lupanol 3-O -diglucoside and leptidin1.
Pharmacology:
A number of studies have been carried out on the
galactagogue property of the plant in laboratory animals.
Studies on the lactogenic property of L.reticulata were
carried out on lactating rats using pup weight, body weight of
mother rats, and histopathological study of lactating mammary
gland, as well as the secretory rating, parenchyma percentage,
estimation of glycogen content (of the abdominal mammary glands)
and the protein content (of the pectoral mammary glands) as
parameters. While both stigmasterol and the ether fraction of
L.reticulata showed lactogenic effect, as assessed by all
these parameters, stigmasterol was found to be more potent2.A
herbal preparation with L.reticulata as one of the nine
constituents is said to exert beneficial effects on the
gametogenic and androgenic functions of the testes of animals.
It showed anabolic cum androgen like activity as evidenced by
the dose related growth of the ventral prostate and the systemic
increase in the weights as well as the secretions of the
accessory sex organs of castrated adult mice3.
Clinical Studies:
The lactogenic/galactagogue effect of L.reticulata has
been clinically assessed by many investigators. These studies
have been mainly carried out on the commercial preparation of
Leptaden.
Toxicity:
On acute toxicity studies, L.reticulata (aqueous extract)
and leptaden administered orally for three alternate days, and
three consecutive days to rats, were safely tolerated up to a
dose of 3.125 g/kg. An increase in dose led to an increase in
mortality. Post mortem, subcutaneous peticheal hemorrhage was
noted, whilst the liver, kidney and heart showed no apparent
change4
Indications:
The plant is stimulant and restorative and shows anti-bacterial
activity against gram-positive and gram-negative bacteria.
Disclaimer:
The authenticity of the above
information are not verified and established by us. You are
requested to get it verified. The above given information are
collected from various sources may be used for academic purpose.
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